EVIDENCE FOR TRUSTED DIGITAL REPOSITORY REVIEWS: AN ANALYSIS OF PERSPECTIVES

Jonathan David Crabtree: Evidence for Trusted Digital Repository Reviews: An Analysis of Perspectives(Under the direction of Dr. Helen R. Tibbo) Building trust in our research infrastructure is important for the future of the academy. Trust in research data repositories is critical as they provide the evidence for past discoveries as well as the input for future discoveries. Archives and repositories are examining their options for trustworthy review, audit, and certification as a means to build trust within their content creator and user communities. One option these institutions have is to increase and demonstrate their trustworthiness is to apply for the CoreTrustSeal. Applicants for the CoreTrustSeal are becoming more numerous and diverse, ranging general purpose repositories, preservation infrastructure providers, and domain repositories. This demand for certification and the subjective nature of decisions around levels of CORETrustSeal compliance drives this dissertation. It is a study of the review process and its veracity and consistency in determining the trustworthiness of applicant repositories. Several assumptions underlie this work. First, audits and reviews must be based on evidence supplied by the repository under scrutiny; second, and not all reviewers will approach a piece of evidence in the same fashion or give it the same weight. Third, the value and veracity of required evidence may be subject to reviewers’ diverse perspectives and diverse repository community norms. This research used a thematic qualitative analysis approach to identify similarities and differences in CoreTrustSeal reviewers’ responses during semi-structured interviews in order to better understand potential subjective differences among respondents. The participants’ non-probabilistic sample represented a balance in perspectives across three anticipated categories: administrator, archivist, and technologist. Themes converged around several key concepts. Nearly all participants felt they were performing a peer review process and working to help the repository community and the research enterprise. Reviewers were questioned about the various CoreTrustSeal application requirements and which ones they felt were the most important. No clear evidence emerged to indicate that variations in perspectives affected the subjective review of application evidence. The same categories of evidence were often selected and identified as being critical across all three categories (i.e., administrator, archivist, and technologist). Many valuable suggestions from participants were recorded and can be implemented to ensure the consistency and sustainability of this trusted repository review process. These suggestions and concepts were also very evenly distributed across the three perspectives. The balance in perspectives is potentially due to participants’ experience levels and their years of experience in various positions, holding many responsibilities, within the organizations they represented.Doctor of Philosoph

Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements

Burkholderia mallei (Bm), the causative agent of the predominately equine disease glanders, is a genetically uniform species that is very closely related to the much more diverse species Burkholderia pseudomallei (Bp), an opportunistic human pathogen and the primary cause of melioidosis. To gain insight into the relative lack of genetic diversity within Bm, we performed whole-genome comparative analysis of seven Bm strains and contrasted these with eight Bp strains. The Bm core genome (shared by all seven strains) is smaller in size than that of Bp, but the inverse is true for the variable gene sets that are distributed across strains. Interestingly, the biological roles of the Bm variable gene sets are much more homogeneous than those of Bp. The Bm variable genes are found mostly in contiguous regions flanked by insertion sequence (IS) elements, which appear to mediate excision and subsequent elimination of groups of genes that are under reduced selection in the mammalian host. The analysis suggests that the Bm genome continues to evolve through random IS-mediated recombination events, and differences in gene content may contribute to differences in virulence observed among Bm strains. The results are consistent with the view that Bm recently evolved from a single strain of Bp upon introduction into an animal host followed by expansion of IS elements, prophage elimination, and genome rearrangements and reduction mediated by homologous recombination across IS elements

The TRUST Principles for digital repositories.

As information and communication technology has become pervasive in our society, we are increasingly dependent on both digital data and repositories that provide access to and enable the use of such resources. Repositories must earn the trust of the communities they intend to serve and demonstrate that they are reliable and capable of appropriately managing the data they hold. Following a year-long public discussion and building on existing community consensus1, several stakeholders, representing various segments of the digital repository community, have collaboratively developed and endorsed a set of guiding principles to demonstrate digital repository trustworthiness. Transparency, Responsibility, User focus, Sustainability and Technology: the TRUST Principles provide a common framework to facilitate discussion and implementation of best practice in digital preservation by all stakeholders.Proyecto de Enlace de Biblioteca

Using Sybil for interactive comparative genomics of microbes on the web

Motivation: Analysis of multiple genomes requires sophisticated tools that provide search, visualization, interactivity and data export. Comparative genomics datasets tend to be large and complex, making development of these tools difficult. In addition to scalability, comparative genomics tools must also provide user-friendly interfaces such that the research scientist can explore complex data with minimal technical expertise

Draft Genome of the Filarial Nematode Parasite \u3ci\u3eBrugia malayi\u3c/i\u3e

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the ∼90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict ∼11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during ∼350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design

Los principios TRUST en los repositorios digitales

Con la adopción cada vez más generalizada de las TICs en nuestra sociedad, dependemos cada vez más de los datos digitales y de los repositorios que brindan acceso a ese tipo de recursos y nos permiten utilizarlos. Los repositorios deben ganarse la confianza de las comunidades a las que pretenden brindar servicios y demostrar que son confiables y capaces de administrar adecuadamente los datos que contienen. Tras un debate público que se prolongó durante un año y en función del consenso actual de la comunidad, varias partes interesadas, que representan diversos segmentos de la comunidad de los repositorios digitales, han colaborado para desarrollar y avalar un conjunto de principios rectores, para demostrar que el repositorio digital es confiable. Estos principios abarcan la Transparencia, la Responsabilidad, el Foco en el Usuario, la Sostenibilidad y la Tecnología, y presentan un marco común para facilitar el debate y la implementación de las mejores prácticas en cuanto a preservación digital en beneficio de todas las partes interesadas.Este artículo es una traducción de: Lin, D., Crabtree, J., Dillo, I., Downs, R. R., Edmunds, R., Giaretta, D., De Giusti, M., L’Hours, H., Hugo, W., Jenkyns, R., Khodiyar, V., Martone, M. E., Mokrane, M., Navale, V., Petters, J., Sierman, B., Sokolova, D. V., Stockhause, M., & Westbrook, J. (2020). The TRUST Principles for digital repositories. Scientific Data, 7(1), 144. https://doi.org/10.1038/s41597-020-0486-7Servicio de Difusión de la Creación Intelectua

Los principios TRUST en los repositorios digitales

Con la adopción cada vez más generalizada de las TICs en nuestra sociedad, dependemos cada vez más de los datos digitales y de los repositorios que brindan acceso a ese tipo de recursos y nos permiten utilizarlos. Los repositorios deben ganarse la confianza de las comunidades a las que pretenden brindar servicios y demostrar que son confiables y capaces de administrar adecuadamente los datos que contienen. Tras un debate público que se prolongó durante un año y en función del consenso actual de la comunidad, varias partes interesadas, que representan diversos segmentos de la comunidad de los repositorios digitales, han colaborado para desarrollar y avalar un conjunto de principios rectores, para demostrar que el repositorio digital es confiable. Estos principios abarcan la Transparencia, la Responsabilidad, el Foco en el Usuario, la Sostenibilidad y la Tecnología, y presentan un marco común para facilitar el debate y la implementación de las mejores prácticas en cuanto a preservación digital en beneficio de todas las partes interesadas.Este artículo es una traducción de: Lin, D., Crabtree, J., Dillo, I., Downs, R. R., Edmunds, R., Giaretta, D., De Giusti, M., L’Hours, H., Hugo, W., Jenkyns, R., Khodiyar, V., Martone, M. E., Mokrane, M., Navale, V., Petters, J., Sierman, B., Sokolova, D. V., Stockhause, M., & Westbrook, J. (2020). The TRUST Principles for digital repositories. Scientific Data, 7(1), 144. https://doi.org/10.1038/s41597-020-0486-7Servicio de Difusión de la Creación Intelectua

Los principios TRUST en los repositorios digitales

Con la adopción cada vez más generalizada de las TICs en nuestra sociedad, dependemos cada vez más de los datos digitales y de los repositorios que brindan acceso a ese tipo de recursos y nos permiten utilizarlos. Los repositorios deben ganarse la confianza de las comunidades a las que pretenden brindar servicios y demostrar que son confiables y capaces de administrar adecuadamente los datos que contienen. Tras un debate público que se prolongó durante un año y en función del consenso actual de la comunidad, varias partes interesadas, que representan diversos segmentos de la comunidad de los repositorios digitales, han colaborado para desarrollar y avalar un conjunto de principios rectores, para demostrar que el repositorio digital es confiable. Estos principios abarcan la Transparencia, la Responsabilidad, el Foco en el Usuario, la Sostenibilidad y la Tecnología, y presentan un marco común para facilitar el debate y la implementación de las mejores prácticas en cuanto a preservación digital en beneficio de todas las partes interesadas.Este artículo es una traducción de: Lin, D., Crabtree, J., Dillo, I., Downs, R. R., Edmunds, R., Giaretta, D., De Giusti, M., L’Hours, H., Hugo, W., Jenkyns, R., Khodiyar, V., Martone, M. E., Mokrane, M., Navale, V., Petters, J., Sierman, B., Sokolova, D. V., Stockhause, M., & Westbrook, J. (2020). The TRUST Principles for digital repositories. Scientific Data, 7(1), 144. https://doi.org/10.1038/s41597-020-0486-7Servicio de Difusión de la Creación Intelectua

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy